Gamma-aminobutyric acidA receptor structure and function.
نویسندگان
چکیده
منابع مشابه
Cloning of genomic and cDNA sequences encoding an invertebrate gamma-aminobutyric acidA receptor subunit.
11. Shivers, B. D., Killisch, I., Sprengel, R., Sontheimer, H., Kohler, M., Schofield, P. R. & Seeburg, P. H. (1989) Neuron 3,327-337 Sieghart, W. ( I 989) Trends Pharmacol. Sci. 10,407-41 1 Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P. & Barnard, E. A. (1 988) Neuron I , 937-947 Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P. & Barnard, E. A. ( 1989) Mol. Brain Res. 5,305-3 1...
متن کاملMolecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.
Although gamma-aminobutyric acid (GABA)A receptor alpha subunits are important for benzodiazepine (BZD) binding and GABA-current potentiation by BZDs, the presence of a gamma subunit is required for high affinity BZD effects. To determine which regions unique to the gamma2S subunit confer BZD binding and potentiation, we generated chimeric protein combinations of rat gamma2S and alpha1 subunits...
متن کاملMapping the benzodiazepine photoaffinity-labelling site with sequence-specific gamma-aminobutyric acidA-receptor antibodies.
The gamma-aminobutyric acidA (GABAA) receptor purified from adult bovine cerebral cortex was photoaffinity-labelled with the agonist benzodiazepine [3H]flunitrazepam and the radioactivity shown to be coincident with a band with Mr 53,000 that was recognized by three anti-(GABAA receptor alpha 1 subunit sequence)-specific antibodies. Complete and limited CNBr cleavage of the purified photoaffini...
متن کاملGamma‐aminobutyric acidA receptor agonist, muscimol, increases KiSS‐1 gene expression in hypothalamic cell models
Purpose Accumulating evidence indicates that hypothalamic kisspeptin plays a pivotal role in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis. In this study, the direct action of the gamma-aminobutyric acid (GABA)A receptor agonist on kisspeptin-expressing neuronal cells was examined. Methods A hypothalamic cell model of rat hypothalamic cell line R8 (rHypoE8) cells and primary...
متن کاملModifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam.
We evaluated whether tolerance to the antagonism of bicuculine-induced seizures by diazepam is associated with changes (i) in the content of mRNAs encoding for gamma-aminobutyric acidA (GABAA) receptor subunits, (ii) in the expression density of these subunits, and (iii) in the 1,4-benzodiazepine binding site characteristics in discrete neocortical structures. We found that in diazepam-tolerant...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)41841-8